CIHR Team Grant : E-Rare-6 Joint Transnational Call (European Joint Programme on Rare Diseases Joint Transnational Call 2022) Pre-Proposal
Well-being, Health and Biomedical Discovery
Deadlines
Academic Unit: inquire with unit
Memorial Deadline: Friday 11th, February 2022
External Deadline: Wednesday 16th, February 2022
Description
CIHR-IG is pleased to be partnering with the Fonds de recherche du Québec – Santé (FRQS), Ataxia Canada and approximately 26 international funding organizations in the context of this European Joint Programme on Rare Diseases (EJP RD) call for proposals 2022. CIHR-IG is committed to expanding and improving the diagnosis and treatment of rare diseases by creating the conditions needed to bring together creative, dynamic, interdisciplinary teams of researchers from across Canada and the European Community (EC) to collaborate for better health outcome for the rare disease patient community.
The topic of the call is Development of new analytic tools and pathways to accelerate diagnosis and facilitate diagnostic monitoring of rare diseases.
Projects shall focus on a group of rare diseases or a single rare disease following the European definition i.e. a disease affecting not more than five in 10.000 persons in the European Community, EC associated states, Australia and Canada. Applicants are encouraged to assemble groups of rare diseases based on relevant criteria and commonalities if this leverages added value in sharing resources or expertise.
For more information, please consult EJP RD JTC2022.
Research Areas
This funding opportunity will support transnational research proposals relevant to at least one of the following areas:
- Phenotype-driven diagnosis: integration across different ontologies, integration of shared pathways, digital phenotyping, development of artificial intelligence approaches/applications to extract health related data in aid of diagnosis;
- Prognostic markers/biomarkers investigations for early diagnosis and monitoring;
- Methodologies for solving cases that are currently difficult to analyze due to different underlying mechanisms (e.g. mosaicism, genomic (non-coding) alterations, gene regulation, complex inheritance), including new genomics / functional genomics technologies, multi-omics, mathematics, biostatistics, bioinformatics and artificial intelligence approaches;
- Functional strategies to globally stratify variants of unknown significance (VUS) for clinical use; setting up of (in vitro) systems to distinguish between VUS and pathogenic variants (e.g. confirming disruption of splicing for deep intronic variants, loss of protein function, and gain of toxic protein function);
- Development of pathway models to enable diagnosis, especially for newly discovered diseases that may share underlying molecular mechanisms with already known diseases.
Pre-Proposal to EJP RD Deadline: February 16, 2022
Full Proposal to EJP RD and Abbreviated Application to CIHR (202206ERT): June 15, 2022