Genomics of ASD: Pathways to Biological Convergence and Genetic Therapies – Request for Applications
Well-being, Health and Biomedical Discovery
Deadlines
Academic Unit: inquire with unit
Memorial Deadline: Monday 15th, August 2022
External Deadline: Thursday 18th, August 2022
Description
SFARI Mission
The mission of the Simons Foundation Autism Research Initiative (SFARI) is to improve the understanding, diagnosis and treatment of autism spectrum disorders (ASD) by funding innovative research of the highest quality and relevance.
Grants awarded through this request for applications (RFA) are intended to improve our understanding of the molecular and cellular consequences of genetic risk for ASD, and to provide a foundation for the development of new therapies. Special emphasis is placed on the use of scalable methods, especially as applied to genes that are suitable targets for genetic therapies.
There are three budget tracks, depending on the scope of the project: an Explorer track of up to $400,000 over a period of up to two (2) years; an Expansion track of up to $1,500,000 over a period of up to three (3) years; and a Collaboration track of up to $750,000 per lab over a period of up to three (3) years. All budget figures are inclusive of 20 percent indirect costs.
In this RFA we seek proposals in three different areas, with the common goal of identifying new possibilities for intervention. The first will do so by identifying possible points of biological convergence among multiple genetic risk factors, which might then suggest new therapeutic targets. The second will continue SFARI-supported efforts to characterize the full range of functional variation in genes associated with neurodevelopmental disorders, again with an eye toward informing translational efforts. And the third area will focus on the development of genetically based therapies for select forms of ASD. We also encourage applicants to familiarize themselves with resources that SFARI supports that may accelerate projects, such as our resource of iPS cells, mouse, rat and zebrafish models.
RFA Informational Session
Application Deadline
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