Single-Cell Analysis of Inflammation

Well-being, Health and Biomedical Discovery


Academic Unit: Inquire with Unit

Memorial Deadline: Thursday 14th, November 2019

External Deadline: Tuesday 19th, November 2019



Inflammation is a feature of many diseases and a cross-cutting area of biomedicine. Inflammation mediates the response to chronic and acute tissue injury and infection, driving homeostasis and tissue repair. It is also a driver of fibrosis, cardiovascular disease, inflammatory bowel disease, arthritis, neurodegeneration, adverse events associated with immunotherapies, and many other maladaptive processes. Mapping inflammation in diverse tissues is a path to understanding, diagnosing, and potentially treating many different diseases.

CZI seeks applications aimed toward identifying unifying principles that underlie tissue homeostasis and inflammation at the single cell level. Our goal is to stimulate collaborations across disciplines that will help define a new field. Successful applications will bring together researchers in different experimental, computational, or medical domains. They will address local cell properties and interactions in inflamed tissues and compare them to the properties and interactions of similar cells in healthy tissues. They will increase our understanding of the cell types that mediate inflammation, and their interactions in space and time. The two-year pilot grant period is intended to develop proof-of-concept for the experimental team and the approach, setting up future programs for detailed mechanistic investigations.


The grant budget will be $175K in total costs per participating Principal Investigator over the duration of the two-year project (including no more than 15% indirect costs).

  • If there are two Principal Investigators, the total grant budget will be $350K.
  • If there are three Principal Investigators, the total grant budget will be $525K.

The preliminary budget should detail the support requested for each Principal Investigator. While unequal distribution of funds among PIs is allowed, it should be justified in the application.

Additional information can be found here. 


Funding Sources

Chan Zucherberg Initiative

This opportunity was posted by: RGCS

Last modified: September 24, 2019